| Tissue Specificity | Detected in peripheral blood leukocytes (at protein level). Expressed predominantly in peripheral blood leukocytes and at lower levels, in thymus, spleen, testis, prostate, ovary, brain, small intestine and lung. |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1.interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. |
| Protein Name | Unconventional Myosin-IxbUnconventional Myosin-9b |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-8980692Reactome: R-HSA-8985586Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9035034Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCell CortexPerinuclear RegionCytoskeletonIn Undifferentiated Cells Colocalizes With F-Actin In The Cell Periphery While In Differentiated Cells Its Localization Is Cytoplasmic With The Highest Levels In The Perinuclear Region |
| Alternative Antibody Names | Anti-Unconventional Myosin-Ixb antibodyAnti-Unconventional Myosin-9b antibodyAnti-MYO9B antibodyAnti-MYR5 antibody |
Information sourced from Uniprot.org
