Anti-MYO1C antibody [SRM14806] (STJ11109536)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal MYO1C antibody for use in WB, IF, ICC, IF-P, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IF-P/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14806 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:10000-1:60000IF/ICC, 1:200-1:400IF-P, 1:200-1:400IHC-P, 1:200-1:800ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYO1C |
| Gene ID | 4641 |
| Uniprot ID | MYO1C_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Post Translational Modifications | Isoform 2 contains a N-acetylmethionine at position 1. |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. Isoform 3: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. |
| Protein Name | Unconventional Myosin-IcMyosin I BetaMmi-BetaMmib |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-2029482Reactome: R-HSA-5250924 O00159-3Reactome: R-HSA-9662360Reactome: R-HSA-9662361Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmNucleusCell CortexCell ProjectionStereocilium MembraneCytoplasmic VesicleRuffle MembraneColocalizes With Cabp1 And Cib1 At Cell MarginMembrane Ruffles And Punctate Regions On The Cell MembraneColocalizes In Adipocytes With Glut4 At Actin-Based MembranesColocalizes With Glut4 At Insulin-Induced Ruffles At The Cell MembraneLocalizes Transiently At Cell Membrane To Region Known To Be Enriched In Pip2Activation Of Phospholipase C Results In Its Redistribution To The CytoplasmColocalizes With Rna Polymerase IiTranslocates To Nuclear Speckles Upon Exposure To Inhibitors Of Rna Polymerase Ii TranscriptionIsoform 3: NucleusNucleoplasmNucleolusColocalizes With Rna Polymerase Ii In The NucleusColocalizes With Rna Polymerase I In NucleoliIn The NucleolusIs Localized Predominantly In Dense Fibrillar Component (Dfc) And In Granular Component (Gc)Accumulates Strongly In Dfc And Gc During Activation Of TranscriptionColocalizes With Transcription SitesColocalizes In The Granular Cortex At The Periphery Of The Nucleolus With Rps6Colocalizes In Nucleoplasm With Rps6 And Actin That Are In Contact With Rnp ParticlesColocalizes With Rps6 At The Nuclear Pore Level |
| Alternative Antibody Names | Anti-Unconventional Myosin-Ic antibodyAnti-Myosin I Beta antibodyAnti-Mmi-Beta antibodyAnti-Mmib antibodyAnti-MYO1C antibody |
Information sourced from Uniprot.org