| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYO18B |
| Gene ID: | 84700 |
| Uniprot ID: | MY18B_HUMAN |
| Immunogen Region: | 120-420 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-420 of human MYO18B (NP_115997.5). |
| Immunogen Sequence: | MTSINGEKAQELGSSATPTK KTVPFKRGVRRGDVLLMVAK LDPDSAKPEKTHPHDAPPCK TSPPATDTGKEKKGETSRTP CGSQASTEILAPKAEKTRTG GLGDPGQGTVALKKGEEGQS IVGKGLGTPKTTELKEAEPQ GKDRQGTRPQAQGPGEGVRP GKAEKEGAEPTNTVEKGNVS KDVGSEGKHVRPQIPGRKWG GFLGRRSKWDGPQNKKDKEG VLLSKAEKTGEPQTQMEKT |
| Tissue Specificity | Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus. |
| Function | May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression.restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth. |
| Protein Name | Unconventional Myosin-Xviiib |
| Cellular Localisation | CytoplasmNucleusMyofibrilSarcomerePunctate Pattern In Undifferentiated MyoblastsNuclearOn Primary Cardiomyocytes And Adult MuscleA Partial Sarcomeric Location Was Found In Some Cardiomyocytes |
| Alternative Antibody Names | Anti-Unconventional Myosin-Xviiib antibodyAnti-MYO18B antibody |
Information sourced from Uniprot.org
