| Tissue Specificity | Ubiquitously expressed in various hematopoietic cells. |
| Post Translational Modifications | Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is reduced following epigallocatechin-3-O-gallate treatment. |
| Function | Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion. |
| Protein Name | Myosin Regulatory Light Chain 12bMlc-2aMlc-2Myosin Regulatory Light Chain 2-B - Smooth Muscle IsoformMyosin Regulatory Light Chain 20 KdaMlc20Myosin Regulatory Light Chain Mrlc2Shujun-1 |
| Database Links | Reactome: R-HSA-3928663Reactome: R-HSA-416572Reactome: R-HSA-445355Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Myosin Regulatory Light Chain 12b antibodyAnti-Mlc-2a antibodyAnti-Mlc-2 antibodyAnti-Myosin Regulatory Light Chain 2-B - Smooth Muscle Isoform antibodyAnti-Myosin Regulatory Light Chain 20 Kda antibodyAnti-Mlc20 antibodyAnti-Myosin Regulatory Light Chain Mrlc2 antibodyAnti-Shujun-1 antibodyAnti-MYL12B antibodyAnti-MRLC2 antibodyAnti-MYLC2B antibody |
Information sourced from Uniprot.org
