Anti-MYCN antibody (168-267) (STJ24658)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MYCN (168-267) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYCN |
| Gene ID | 4613 |
| Uniprot ID | MYCN_HUMAN |
| Immunogen Region | 168-267 |
| Immunogen Sequence | AGRAGAALPAELAHPAAECV DPAVVFPFPVNKREPAPVPA APASAPAAGPAVASGAGIAA PAGAPGVAPPRPGGRQTSGG DHKALSTSGEDTLSDSDDED |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 168-267 of human N-Myc/MYCN (NP_005369.2). |
Additional Info
| Tissue Specificity | Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level). |
| Post Translational Modifications | Phosphorylated by GSK3-beta which may promote its degradation. Phosphorylated by AURKA. |
| Function | Positively regulates the transcription of MYCNOS in neuroblastoma cells. |
| Protein Name | N-Myc Proto-Oncogene ProteinClass E Basic Helix-Loop-Helix Protein 37Bhlhe37 |
| Database Links | Reactome: R-HSA-201556Reactome: R-HSA-9839394 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-N-Myc Proto-Oncogene Protein antibodyAnti-Class E Basic Helix-Loop-Helix Protein 37 antibodyAnti-Bhlhe37 antibodyAnti-MYCN antibodyAnti-BHLHE37 antibodyAnti-NMYC antibody |
Information sourced from Uniprot.org