| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYCN |
| Gene ID: | 4613 |
| Uniprot ID: | MYCN_HUMAN |
| Immunogen Region: | 168-267 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 168-267 of human N-Myc/MYCN (NP_005369.2). |
| Immunogen Sequence: | AGRAGAALPAELAHPAAECV DPAVVFPFPVNKREPAPVPA APASAPAAGPAVASGAGIAA PAGAPGVAPPRPGGRQTSGG DHKALSTSGEDTLSDSDDED |
| Tissue Specificity | Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level). |
| Post Translational Modifications | Phosphorylated by GSK3-beta which may promote its degradation. Phosphorylated by AURKA. |
| Function | Positively regulates the transcription of MYCNOS in neuroblastoma cells. |
| Protein Name | N-Myc Proto-Oncogene ProteinClass E Basic Helix-Loop-Helix Protein 37Bhlhe37 |
| Database Links | Reactome: R-HSA-201556Reactome: R-HSA-9839394 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-N-Myc Proto-Oncogene Protein antibodyAnti-Class E Basic Helix-Loop-Helix Protein 37 antibodyAnti-Bhlhe37 antibodyAnti-MYCN antibodyAnti-BHLHE37 antibodyAnti-NMYC antibody |
Information sourced from Uniprot.org