| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2000-1:10000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MYB |
| Gene ID: | 4602 |
| Uniprot ID: | MYB_HUMAN |
| Immunogen Region: | 380-640 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 380-640 of human MYB (NP_005366.2). |
| Immunogen Sequence: | GTILDNVKNLLEFAETLQFI DSFLNTSSNHENSDLEMPSL TSTPLIGHKLTVTTPFHRDQ TVKTQKENTVFRTPAIKRSI LESSPRTPTPFKHALAAQEI KYGPLKMLPQTPSHLVEDLQ DVIKQESDESGIVAEFQENG PPLLKKIKQEVESPTDKSGN FFCSHHWEGDSLNTQLFTQT SPVADAPNILTSSVLMAPAS EDEDNVLKAFTVPKNRSLAS PLQPCSSTWEPASCGKMEE |
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 and leading to its subsequent proteasomal degradation. SUMOylated by TRAF7.leading to MYB transcriptional activity inhibition. Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels. |
| Function | Transcriptional activator.DNA-binding protein that specifically recognize the sequence 5'-YAACGTG-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| Protein Name | Transcriptional Activator MybProto-Oncogene C-Myb |
| Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-9616222Reactome: R-HSA-983231Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Activator Myb antibodyAnti-Proto-Oncogene C-Myb antibodyAnti-MYB antibody |
Information sourced from Uniprot.org