Anti-MXD1 antibody (100-200) (STJ24651)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MXD1 (100-200) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MXD1 |
| Gene ID | 4084 |
| Uniprot ID | MAD1_HUMAN |
| Immunogen Region | 100-200 |
| Immunogen Sequence | KAKLHIKKLEDCDRKAVHQI DQLQREQRHLKRQLEKLGIE RIRMDSIGSTVSSERSDSDR EEIDVDVESTDYLTGDLDWS SSSVSDSDERGSMQSLGSDE G |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MXD1 (NP_002348.1). |
Additional Info
| Post Translational Modifications | Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome. |
| Function | Component of a transcriptional repressor complex together with MAX. In complex with MAX binds to the core DNA sequence 5'-CACGATG-3'. Antagonizes MYC transcriptional activity by competing with MYC for MAX binding. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. |
| Protein Name | Max Dimerization Protein 1Max Dimerizer 1Protein Mad |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Max Dimerization Protein 1 antibodyAnti-Max Dimerizer 1 antibodyAnti-Protein Mad antibodyAnti-MXD1 antibodyAnti-MAD antibody |
Information sourced from Uniprot.org