| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-MVP (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S8MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MVP |
| Gene ID: |
9961 |
| Uniprot ID: |
MVP_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MVP (Q14764). |
| Immunogen Sequence: |
MATEEFIIRIPPYHYIHVLD QNSNVSRVEVGPKTYIRQDN ERVLFAPMRMVTVPPRHYCT VANPVSRDAQGLVLFDVTGQ VRLRHADLEIRLAQDPFPLY |
| Tissue Specificity | Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells. |
| Post Translational Modifications | Phosphorylated on Tyr residues after EGF stimulation. Dephosphorylated by PTPN11. |
| Function | Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. |
| Protein Name | Major Vault ProteinMvpLung Resistance-Related Protein |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmNucleusNuclear Pore ComplexPerinuclear Region5% Found In The Nuclear Pore ComplexTranslocates From The Nucleus To The Cytoplasm Upon Egf Treatment |
| Alternative Antibody Names | Anti-Major Vault Protein antibodyAnti-Mvp antibodyAnti-Lung Resistance-Related Protein antibodyAnti-MVP antibodyAnti-LRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
