• Anti-MUC5AC antibody [SM0517] (STJA0010517)

Anti-MUC5AC antibody [SM0517] (STJA0010517)

SKU:
STJA0010517-50

$315.23
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Host: Mouse
Applications: IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-MUC5AC is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: SM0517
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: IHC/IF (H) 1:200-1:500
Storage Instruction: Store at-20C for up to one year, and avoid repeated freeze-thaw cycles.
Gene Symbol: MUC5AC
Gene ID: 4586
Uniprot ID: MUC5A_HUMAN
Immunogen: Synthesized peptide derived from human MUC5AC
Post Translational Modifications C-, O- and N-glycosylated. O-glycosylated on the second and last Thr of the Thr-/Ser-rich tandem repeats TTPSPVPTTSTTSA. One form of glycosylation is also known as Lewis B (LeB) blood group antigen, a tetrasaccharide consisting of N-acetylglucosamine having a fucosyl residue attached. It has a role as an epitope and antigen and functions as a receptor for H.pylori binding and facilitates infection. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.
Function Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).
Protein Name Mucin-5ac
Muc-5ac
Gastric Mucin
Major Airway Glycoprotein
Mucin-5 Subtype Ac - Tracheobronchial
Tracheobronchial Mucin
Tbm
Database Links Reactome: R-HSA-5083625
Reactome: R-HSA-5083632
Reactome: R-HSA-5083636
Reactome: R-HSA-5621480
Reactome: R-HSA-913709
Reactome: R-HSA-977068
Cellular Localisation Secreted
Alternative Antibody Names Anti-Mucin-5ac antibody
Anti-Muc-5ac antibody
Anti-Gastric Mucin antibody
Anti-Major Airway Glycoprotein antibody
Anti-Mucin-5 Subtype Ac - Tracheobronchial antibody
Anti-Tracheobronchial Mucin antibody
Anti-Tbm antibody
Anti-MUC5AC antibody
Anti-MUC5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance