| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-MUC4 is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
8G7 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Dilution Range: |
IHC-P 1:10-1:50 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Tissue Specificity | Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. |
| Post Translational Modifications | Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. Mucin-4 alpha chain: Highly O-glycosylated. Mucin-4 beta chain: Is predominantly N-glycosylated. |
| Function | Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. |
| Protein Name | Mucin-4Muc-4Ascites SialoglycoproteinAsgpPancreatic Adenocarcinoma MucinTestis MucinTracheobronchial Mucin Cleaved Into - Mucin-4 Alpha ChainAscites Sialoglycoprotein 1Asgp-1 - Mucin-4 Beta ChainAscites Sialoglycoprotein 2Asgp-2 |
| Database Links | Reactome: R-HSA-5083625Reactome: R-HSA-5083632Reactome: R-HSA-5083636Reactome: R-HSA-5621480Reactome: R-HSA-913709Reactome: R-HSA-977068 |
| Cellular Localisation | Mucin-4 Beta Chain: Cell MembraneSingle-Pass Membrane ProteinIsoforms Lacking The Cys-Rich RegionEgf-Like Domains And Transmembrane Region Are SecretedSecretion Occurs By Splicing Or Proteolytic ProcessingMucin-4 Alpha Chain: Cell MembraneSecretedForms A Complex With Mucin-4 Beta Chain At The Cell MembraneIsoform 3: Cell MembraneIsoform 11: SecretedIsoform 15: SecretedIsoform 17: Cell Membrane |
| Alternative Antibody Names | Anti-Mucin-4 antibodyAnti-Muc-4 antibodyAnti-Ascites Sialoglycoprotein antibodyAnti-Asgp antibodyAnti-Pancreatic Adenocarcinoma Mucin antibodyAnti-Testis Mucin antibodyAnti-Tracheobronchial Mucin Cleaved Into - Mucin-4 Alpha Chain antibodyAnti-Ascites Sialoglycoprotein 1 antibodyAnti-Asgp-1 - Mucin-4 Beta Chain antibodyAnti-Ascites Sialoglycoprotein 2 antibodyAnti-Asgp-2 antibodyAnti-MUC4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
