• Human ovarian serous adenocarcinoma tissue was stained with anti-CA-125 (ABT-MUC16) antibody.
  • Human ovarian serous adenocarcinoma tissue was stained with anti-CA-125 (ABT-MUC16) antibody.

Anti-MUC16 antibody [ABT-MUC16] (STJ196871)

SKU:
STJ196871

Current Stock:
Host: Mouse
Applications: IHC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Mucin-16 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: ABT-MUC16
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: WB 500-2000
IHC-P 1:100-500
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MUC16
Gene ID: 94025
Uniprot ID: MUC16_HUMAN
Specificity: This antibody detects endogenous levels of human CA 125. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
Immunogen: Synthesized peptide derived from the human CA 125 the amino acid range External domain of the CA-125 molecule
Post Translational Modifications Heavily O-glycosylated.expresses both type 1 and type 2 core glycans. Heavily N-glycosylated.expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Function Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Protein Name Mucin-16
Muc-16
Ovarian Cancer-Related Tumor Marker Ca125
Ca-125
Ovarian Carcinoma Antigen Ca125
Database Links Reactome: R-HSA-5083625
Reactome: R-HSA-5083632
Reactome: R-HSA-5083636
Reactome: R-HSA-5621480
Reactome: R-HSA-913709
Reactome: R-HSA-977068
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Secreted
Extracellular Space
May Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain
Alternative Antibody Names Anti-Mucin-16 antibody
Anti-Muc-16 antibody
Anti-Ovarian Cancer-Related Tumor Marker Ca125 antibody
Anti-Ca-125 antibody
Anti-Ovarian Carcinoma Antigen Ca125 antibody
Anti-MUC16 antibody
Anti-CA125 antibody

Information sourced from Uniprot.org

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