| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTX1 |
| Gene ID: | 4580 |
| Uniprot ID: | MTX1_HUMAN |
| Immunogen Region: | 186-435 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 186-435 of human MTX1 (NP_942584.2). |
| Immunogen Sequence: | LKVHKISNPWQSPSGTLPAL RTSHGEVISVPHKIITHLRK EVHTFWIDTKNYVEVTRKWY AEAMPFPLNFFLPGRMQRQY MERLQLLTGEHRPEDEEELE KELYREARECLTLLSQRLGS QKFFFGDAPASLDAFVFSYL ALLLQAKLPSGKLQVHLRGL HNLCAYCTHILSLYFPWDGA EVPPQRQTPAGPETEEEPYR RRNQILSVLAGLAAMVGYAL LSGIVSIQRATPARAPGTR |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Involved in transport of proteins into the mitochondrion. Essential for embryonic development. |
| Protein Name | Metaxin-1 Mitochondrial Outer Membrane Import Complex Protein 1 |
| Database Links | Reactome: R-HSA-1268020 Reactome: R-HSA-8949613 Reactome: R-HSA-9013404 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Metaxin-1 antibody Anti-Mitochondrial Outer Membrane Import Complex Protein 1 antibody Anti-MTX1 antibody Anti-MTX antibody Anti-MTXN antibody |
Information sourced from Uniprot.org