| Short Description : | Rabbit polyclonal anti-Melatonin receptor type 1A (191-240 aa) for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTNR1A |
| Gene ID: | 4543 |
| Uniprot ID: | MTR1A_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human MTR1A at the amino acid range 191-240 |
| Immunogen Region: | 191-240 aa |
| Specificity: | MEL-1A-R Polyclonal Antibody detects endogenous levels of MEL-1A-R protein. |
| Function | High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission. |
| Protein Name | Melatonin Receptor Type 1aMel-1a-RMel1a Receptor |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Melatonin Receptor Type 1a antibodyAnti-Mel-1a-R antibodyAnti-Mel1a Receptor antibodyAnti-MTNR1A antibody |
Information sourced from Uniprot.org
