Anti-MTMR6 antibody (382-621) (STJ117543)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTMR6 (382-621) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTMR6 |
| Gene ID | 9107 |
| Uniprot ID | MTMR6_HUMAN |
| Immunogen Region | 382-621 |
| Immunogen Sequence | RCGQLDGDPKEVSPVFTQFL ECVWHLTEQFPQAFEFSEAF LLQIHEHIHSCQFGNFLGNC QKEREELKLKEKTYSLWPFL LEDQKKYLNPLYSSESHRFT VLEPNTVSFNFKFWRNMYHQ FDRTLHPRQSVFNIIMNMNE QNKQLEKDIKDLESKIKQRK NKQTDGILTKELLHSVHPES PNLKTSLCFKEQTLLPVNDA LRTIEGSSPADNRYSEYAEE FSKSEPAVVSLEYGVARMT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_004676.3). |
Additional Info
| Tissue Specificity | Expressed in CD4+ T-cells. |
| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels. |
| Protein Name | Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr6Myotubularin-Related Protein 6Phosphatidylinositol-3-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-1660499 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum-Golgi Intermediate CompartmentEndoplasmic ReticulumCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SidePerinuclear RegionLocalizes To Ruffles During Egf-Induced MacropinocytosisColocalizes With Mtmr9 To The Perinuclear RegionPartially Localizes To The Endoplasmic ReticulumCo-Localizes With Rab1b To The Endoplasmic Reticulum-Golgi Intermediate Compartment And To The Peri-Golgi Region |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr6 antibodyAnti-Myotubularin-Related Protein 6 antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-MTMR6 antibody |
Information sourced from Uniprot.org