| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTMR4 |
| Gene ID: |
9110 |
| Uniprot ID: |
MTMR4_HUMAN |
| Immunogen Region: |
920-1195 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 920-1195 of human MTMR4 (NP_004678.3). |
| Immunogen Sequence: |
GEATPRRLLSYGCCSKRPNS KQMRATGPCFGGQWAQREGV KSPVCSSHSNGHCTGPGGKN QMWLSSHPKQVSSTKPVPLN CPSPVPPLYLDDDGLPFPTD VIQHRLRQIEAGYKQEVEQL RRQVRELQMRLDIRHCCAPP AEPPMDYEDDFTCLKESDGS DTEDFGSDHSEDCLSEASWE PVDKKETEVTRWVPDHMASH CYNCDCEFWLAKRRHHCRNC GNVFCAGCCHLKLPIPDQQ |
| Tissue Specificity | Expressed in brain, heart, kidney, spleen, liver, colon, testis, muscle, placenta, thyroid gland, pancreas, ovary, prostate, skin, peripheral blood, and bone marrow. |
| Post Translational Modifications | Ubiquitinated. Ubiquitination by NEDD4 probably leads to proteasomal degradation. Phosphorylated by CDK1 during mitosis. |
| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes. Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation. By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response. Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis. Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes. |
| Protein Name | Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr4Fyve Domain-Containing Dual Specificity Protein Phosphatase 2Fyve-Dsp2Myotubularin-Related Protein 4Phosphatidylinositol-3 -5-Bisphosphate 3-PhosphataseZinc Finger Fyve Domain-Containing Protein 11 |
| Database Links | Reactome: R-HSA-1660516Reactome: R-HSA-1660517Reactome: R-HSA-2173788 |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinRecycling Endosome MembraneLate Endosome MembraneCytoplasmic VesiclePhagosome Membrane |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr4 antibodyAnti-Fyve Domain-Containing Dual Specificity Protein Phosphatase 2 antibodyAnti-Fyve-Dsp2 antibodyAnti-Myotubularin-Related Protein 4 antibodyAnti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 11 antibodyAnti-MTMR4 antibodyAnti-KIAA0647 antibodyAnti-ZFYVE11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
