Anti-MTM1 antibody (241-290) (STJ94317)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human Myotubularin. AA range:241-290
General Information
| Short Description | Rabbit polyclonal anti-Myotubularin (241-290) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTM1 |
| Gene ID | 4534 |
| Uniprot ID | MTM1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Myotubularin. AA range:241-290 |
| Immunogen Region | 241-290 |
| Specificity | Myotubularin Polyclonal Antibody detects endogenous levels of Myotubularin protein. |
Additional Info
| Function | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels. |
| Protein Name | MyotubularinPhosphatidylinositol-3 -5-Bisphosphate 3-PhosphatasePhosphatidylinositol-3-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCell ProjectionFilopodiumRuffleLate EndosomeMyofibrilSarcomereLocalizes As A Dense Cytoplasmic NetworkAlso Localizes To The Plasma MembraneIncluding Plasma Membrane Extensions Such As Filopodia And RufflesPredominantly Located In The Cytoplasm Following Interaction With Mtmr12Recruited To The Late Endosome Following Egf StimulationIn Skeletal MusclesCo-Localizes With Mtmr12 In The Sarcomere |
| Alternative Antibody Names | Anti-Myotubularin antibodyAnti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-MTM1 antibodyAnti-CG2 antibody |
Information sourced from Uniprot.org