| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MTERF (61-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTERF1 |
| Gene ID: |
7978 |
| Uniprot ID: |
MTEF1_HUMAN |
| Immunogen Region: |
61-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 61-240 of human MTERF (NP_008911.1). |
| Immunogen Sequence: |
KCHNTDSEPLKNEDLLKNLL TMGVDIDMARKRQPGVFHRM ITNEQDLKMFLLSKGASKEV IASIISRYPRAITRTPENLS KRWDLWRKIVTSDLEIVNIL ERSPESFFRSNNNLNLENNI KFLYSVGLTRKCLCRLLTNA PRTFSNSLDLNKQMVEFLQA AGLSLGHNDPADFVRKIIFK |
| Post Translational Modifications | Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation. |
| Function | Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene.this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. |
| Protein Name | Transcription Termination Factor 1 - MitochondrialMitochondrial Transcription Termination Factor 1MterfMterf1 |
| Database Links | Reactome: R-HSA-163316Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Transcription Termination Factor 1 - Mitochondrial antibodyAnti-Mitochondrial Transcription Termination Factor 1 antibodyAnti-Mterf antibodyAnti-Mterf1 antibodyAnti-MTERF1 antibodyAnti-MTERF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
