| Post Translational Modifications | Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation. |
| Function | Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene.this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. |
| Protein Name | Transcription Termination Factor 1 - MitochondrialMitochondrial Transcription Termination Factor 1MterfMterf1 |
| Database Links | Reactome: R-HSA-163316Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Transcription Termination Factor 1 - Mitochondrial antibodyAnti-Mitochondrial Transcription Termination Factor 1 antibodyAnti-Mterf antibodyAnti-Mterf1 antibodyAnti-MTERF1 antibodyAnti-MTERF antibody |
Information sourced from Uniprot.org
