Anti-MTA3 antibody (40-330) (STJ24626)

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STJ24626
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Short Description :Rabbit polyclonal MTA3 (40-330) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ELISA
Host:Rabbit
Reactivity:Human/Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:Lot specific
Purification:Affinity purification
Dilution Range:WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:MTA3
Gene ID:57504
Uniprot ID:MTA3_HUMAN
Immunogen Region:40-330
Immunogen Sequence:AKVVCFYRRRDISNTLIMLA DKHAKEIEEESETTVEADLT DKQKHQLKHRELFLSRQYES LPATHIRGKCSVALLNETES VLSYLDKEDTFFYSLVYDPS LKTLLADKGEIRVGPRYQAD IPEMLLEGESDEREQSKLEV KVWDPNSPLTDRQIDQFLVV ARAVGTFARALDCSSSVRQP SLHMSAAAASRDITLFHAMD TLYRHSYDLSSAISVLVPLG GPVLCRDEMEEWSASEASL
Specificity:Recombinant fusion protein containing a sequence corresponding to amino acids 40-330 of human MTA3 (NP_065795.1).
Tissue Specificity Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.
Function Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Protein Name Metastasis-Associated Protein Mta3
Database Links Reactome: R-HSA-3214815
Reactome: R-HSA-427389
Reactome: R-HSA-73762
Reactome: R-HSA-8943724
Reactome: R-HSA-9679191
Reactome: R-HSA-9843940
Reactome: R-HSA-9844594
Reactome: R-HSA-9845323
Cellular Localisation Nucleus
Cytoplasm
Alternative Antibody Names Anti-Metastasis-Associated Protein Mta3 antibody
Anti-MTA3 antibody
Anti-KIAA1266 antibody

Information sourced from Uniprot.org