| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
MSX1 |
| Gene ID: |
4487 |
| Uniprot ID: |
MSX1_HUMAN |
| Immunogen Region: |
1-120 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human MSX1 (NP_002439.2). |
| Immunogen Sequence: |
MAPAADMTSLPLGVKVEDSA FGKPAGGGAGQAPSAAAATA AAMGADEEGAKPKVSPSLLP FSVEALMADHRKPGAKESAL APSEGVQAAGGSAQPLGVPP GSLGAPDAPSSPRPLGHFSV |
| Post Translational Modifications | Sumoylated by PIAS1, desumoylated by SENP1. Sumoylation of Lys-15 and Lys-133 not required for interaction with H1-5, transcriptional repression, inhibition of myoblast differentiation, or binding to gene promoters. |
| Function | Acts as a transcriptional repressor. Capable of transcription autoinactivation. Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR. Represses transcription of myoblast differentiation factors. Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1. Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells. At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells. May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme. Required for BMP4 expression in dental mesenchyme cells. Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells. Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells. Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells. At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as an homeostatic regulator of the cell cycle. Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN. Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation. Plays a role in embryonic bone formation of the middle ear, skull and nasal bones. Required for correct formation and thickness of the nail plate. May play a role in limb-pattern formation. |
| Protein Name | Homeobox Protein Msx-1Homeobox Protein Hox-7Msh Homeobox 1-Like Protein |
| Database Links | Reactome: R-HSA-9834899 |
| Cellular Localisation | NucleusInteraction With Pias1 Is Required For Localization To The Nuclear Periphery |
| Alternative Antibody Names | Anti-Homeobox Protein Msx-1 antibodyAnti-Homeobox Protein Hox-7 antibodyAnti-Msh Homeobox 1-Like Protein antibodyAnti-MSX1 antibodyAnti-HOX7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
