| Short Description : | Rabbit polyclonal anti-Methylsterol monooxygenase 1 (212-262 aa) for use in WB and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MSMO1 |
| Gene ID: | 6307 |
| Uniprot ID: | MSMO1_HUMAN |
| Immunogen: | Synthesized peptide derived from the human MSMO1 at the amino acid range 212-262 |
| Immunogen Region: | 212-262 aa |
| Specificity: | This antibody detects endogenous levels of MSMO1 at Human/Mouse/Rat |
| Function | Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol. Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)-cholecalciferol), a second-generation vitamin D analog, into 1alpha,2beta,25-trihydroxy vitamin D3.this reaction occurs via enzymatic hydroxylation and spontaneous O-dehydroxypropylation. |
| Protein Name | Methylsterol Monooxygenase 1C-4 Methylsterol OxidaseSterol-C4-Methyl Oxidase |
| Database Links | Reactome: R-HSA-191273 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Methylsterol Monooxygenase 1 antibodyAnti-C-4 Methylsterol Oxidase antibodyAnti-Sterol-C4-Methyl Oxidase antibodyAnti-MSMO1 antibodyAnti-DESP4 antibodyAnti-ERG25 antibodyAnti-SC4MOL antibody |
Information sourced from Uniprot.org
