Anti-MSLN antibody (296-606) (STJ27944)

Name: Anti-MSLN antibody (296-606) (STJ27944)
SKU: STJ27944
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ27944

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Short Description	Rabbit polyclonal MSLN (296-606) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	MSLN
Gene ID	10232
Uniprot ID	MSLN_HUMAN
Immunogen Region	296-606
Immunogen Sequence	EVEKTACPSGKKAREIDESL IFYKKWELEACVDAALLATQ MDRVNAIPFTYEQLDVLKHK LDELYPQGYPESVIQHLGYL FLKMSPEDIRKWNVTSLETL KALLEVNKGHEMSPQAPRRP LPQVATLIDRFVKGRGQLDK DTLDTLTAFYPGYLCSLSPE ELSSVPPSSIWAVRPQDLDT CDPRQLDVLYPKARLAFQNM NGSEYFVKIQSFLGGAPTED LKALSQQNVSMDLATFMKL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 296-606 of human Mesothelin (NP_037536.2).

Tissue Specificity	Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Post Translational Modifications	Both MPF and the cleaved form of mesothelin are N-glycosylated. Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
Function	Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Protein Name	Mesothelin Cak1 Antigen Pre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor Mpf - Mesothelin - Cleaved Form
Database Links	Reactome: R-HSA-163125 Reactome: R-HSA-381426 Reactome: R-HSA-8957275
Cellular Localisation	Cell Membrane Lipid-Anchor Gpi-Anchor Golgi Apparatus Megakaryocyte-Potentiating Factor: Secreted Isoform 3: Secreted
Alternative Antibody Names	Anti-Mesothelin antibody Anti-Cak1 Antigen antibody Anti-Pre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor antibody Anti-Mpf - Mesothelin - Cleaved Form antibody Anti-MSLN antibody Anti-MPF antibody

Information sourced from Uniprot.org