Anti-MRP1 antibody [MRPm5] (STJ16100889)

SKU:
STJ16100889-1

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Host: Mouse
Applications: IHC-F/IHC-P/ICC/FC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-MRP1 is suitable for use in Immunohistochemistry, Immunocytochemistry, Flow Cytometry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: MRPm5
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: PBS with 0.1% BSA and 0.02% sodium azide
Purification: Protein G purified
Concentration: 100 ug/mL
Dilution Range: IHC-F
IHC-P 1:20
ICC
FC
WB 1:50
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: MSH3
Gene ID: 4437
Uniprot ID: MSH3_HUMAN
Immunogen: bacterial fusion protein of MRP1 amino acids 986-1204
Function Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Protein Name Dna Mismatch Repair Protein Msh3
Hmsh3
Divergent Upstream Protein
Dup
Mismatch Repair Protein 1
Mrp1
Database Links Reactome: R-HSA-5358606
Reactome: R-HSA-5632927
Reactome: R-HSA-5632928
Alternative Antibody Names Anti-Dna Mismatch Repair Protein Msh3 antibody
Anti-Hmsh3 antibody
Anti-Divergent Upstream Protein antibody
Anti-Dup antibody
Anti-Mismatch Repair Protein 1 antibody
Anti-Mrp1 antibody
Anti-MSH3 antibody
Anti-DUC1 antibody
Anti-DUG antibody

Information sourced from Uniprot.org

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