| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MRM3 |
| Gene ID: | 55178 |
| Uniprot ID: | MRM3_HUMAN |
| Immunogen Region: | 1-420 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-420 of human MRM3 (NP_060616.1). |
| Immunogen Sequence: | MAALVRPARFVVRPLLQVVQ AWDLDARRWVRALRRSPVKV VFPSGEVVEQKRAPGKQPRK APSEASAQEQREKQPLEESA SRAPSTWEESGLRYDKAYPG DRRLSSVMTIVKSRPFREKQ GKILLEGRRLISDALKAGAV PKMFFFSRLEYLKELPVDKL KGVSLIKVKFEDIKDWSDLV TPQGIMGIFAKPDHVKMTYP KTQLQHSLPLLLICDNLRDP GNLGTILRSAAGAGCSKVL |
| Tissue Specificity | Expressed at same level in normal liver and hepatocarcinoma. |
| Function | S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Also required for formation of 2'-O-methyluridine at position 1369 (Um1369) mediated by MRM2. |
| Protein Name | Rrna Methyltransferase 3 - Mitochondrial16s RrnaGuanosine(1370-2'-O-Methyltransferase16s Rrna Gm1370 2'-O-MethyltransferaseRna Methyltransferase-Like Protein 1 |
| Database Links | Reactome: R-HSA-6793080 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Rrna Methyltransferase 3 - Mitochondrial antibodyAnti-16s Rrna antibodyAnti-Guanosine(1370-2'-O-Methyltransferase antibodyAnti-16s Rrna Gm1370 2'-O-Methyltransferase antibodyAnti-Rna Methyltransferase-Like Protein 1 antibodyAnti-MRM3 antibodyAnti-RNMTL1 antibodyAnti-HC90 antibody |
Information sourced from Uniprot.org