| Host: | Rabbit |
| Applications: | WB/IP |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-MRE11A (290-485) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000IP 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MRE11 |
| Gene ID: | 4361 |
| Uniprot ID: | MRE11_HUMAN |
| Immunogen Region: | 290-485 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-485 of human MRE11 (NP_005582.1). |
| Immunogen Sequence: | KGRKMNMHKIPLHTVRQFFM EDIVLANHPDIFNPDNPKVT QAIQSFCLEKIEEMLENAER ERLGNSHQPEKPLVRLRVDY SGGFEPFSVLRFSQKFVDRV ANPKDIIHFFRHREQKEKTG EEINFGKLITKPSEGTTLRV EDLVKQYFQTAEKNVQLSLL TERGMGEAVQEFVDKEEKDA IEELVKYQLEKTQRFL |
| Post Translational Modifications | Ubiquitinated following DNA damage. Ubiquitination triggers interaction with UBQLN4, leading to MRE11 removal from chromatin and degradation by the proteasome. |
| Function | Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation. |
| Protein Name | Double-Strand Break Repair Protein Mre11Double-Strand Break Repair Protein Mre11aMeiotic Recombination 11 Homolog 1Mre11 Homolog 1Meiotic Recombination 11 Homolog AMre11 Homolog A |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-2559586Reactome: R-HSA-3270619Reactome: R-HSA-5685938Reactome: R-HSA-5685939Reactome: R-HSA-5685942Reactome: R-HSA-5693548Reactome: R-HSA-5693554Reactome: R-HSA-5693565Reactome: R-HSA-5693568Reactome: R-HSA-5693571Reactome: R-HSA-5693579Reactome: R-HSA-5693607Reactome: R-HSA-5693616Reactome: R-HSA-6804756Reactome: R-HSA-69473Reactome: R-HSA-912446Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709570Reactome: R-HSA-9709603 |
| Cellular Localisation | NucleusChromosomeTelomereLocalizes To Discrete Nuclear Foci After Treatment With Genotoxic Agents |
| Alternative Antibody Names | Anti-Double-Strand Break Repair Protein Mre11 antibodyAnti-Double-Strand Break Repair Protein Mre11a antibodyAnti-Meiotic Recombination 11 Homolog 1 antibodyAnti-Mre11 Homolog 1 antibodyAnti-Meiotic Recombination 11 Homolog A antibodyAnti-Mre11 Homolog A antibodyAnti-MRE11 antibodyAnti-HNGS1 antibodyAnti-MRE11A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
