Anti-MRC2 antibody (120-300) (STJ111900)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MRC2 (120-300) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MRC2 |
| Gene ID | 9902 |
| Uniprot ID | MRC2_HUMAN |
| Immunogen Region | 120-300 |
| Immunogen Sequence | RWHCRTLGDQLSLLLGARTS NISKPGTLERGDQTRSGQWR IYGSEEDLCALPYHEVYTIQ GNSHGKPCTIPFKYDNQWFH GCTSTGREDGHLWCATTQDY GKDERWGFCPIKSNDCETFW DKDQLTDSCYQFNFQSTLSW REAWASCEQQGADLLSITEI HEQTYINGLLTGYSSTLWIG L |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 120-300 of human MRC2 (NP_006030.2). |
Additional Info
| Tissue Specificity | Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. |
| Post Translational Modifications | N-glycosylated. |
| Function | May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs). |
| Protein Name | C-Type Mannose Receptor 2C-Type Lectin Domain Family 13 Member EEndocytic Receptor 180Macrophage Mannose Receptor 2Urokinase-Type Plasminogen Activator Receptor-Associated ProteinUpar-Associated ProteinUrokinase Receptor-Associated ProteinCd Antigen Cd280 |
| Database Links | Reactome: R-HSA-1236978 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-C-Type Mannose Receptor 2 antibodyAnti-C-Type Lectin Domain Family 13 Member E antibodyAnti-Endocytic Receptor 180 antibodyAnti-Macrophage Mannose Receptor 2 antibodyAnti-Urokinase-Type Plasminogen Activator Receptor-Associated Protein antibodyAnti-Upar-Associated Protein antibodyAnti-Urokinase Receptor-Associated Protein antibodyAnti-Cd Antigen Cd280 antibodyAnti-MRC2 antibodyAnti-CLEC13E antibodyAnti-ENDO180 antibodyAnti-KIAA0709 antibodyAnti-UPARAP antibody |
Information sourced from Uniprot.org