| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MOV10 |
| Gene ID: | 4343 |
| Uniprot ID: | MOV10_HUMAN |
| Immunogen Region: | 800-900 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 800-900 of human MOV10 (Q9HCE1). |
| Immunogen Sequence: | AATVTSYLKLLLAPSSKKGK ARLSPRSVGVISPYRKQVEK IRYCITKLDRELRGLDDIKD LKVGSVEEFQGQERSVILIS TVRSSQSFVQLDLDFNLGFL K |
| Post Translational Modifications | Ubiquitinated by the DCX(DCAF12) complex that specifically recognizes the glutamate-leucine (Glu-Leu) degron at the C-terminus, leading to its degradation. (Microbial infection) Cleaved and targeted for degradation by picornavirus proteases. |
| Function | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway. Inhibits also hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription. Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7. Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor. (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. |
| Protein Name | Helicase Mov-10 Armitage Homolog Moloney Leukemia Virus 10 Protein |
| Database Links | Reactome: R-HSA-1912408 Reactome: R-HSA-2559580 Reactome: R-HSA-2559585 Reactome: R-HSA-4086398 Reactome: R-HSA-5628897 Reactome: R-HSA-5687128 Reactome: R-HSA-8853884 Reactome: R-HSA-8934593 Reactome: R-HSA-8936459 Reactome: R-HSA-8943723 Reactome: R-HSA-8948700 Reactome: R-HSA-8986944 Reactome: R-HSA-9018519 Reactome: R-HSA-9022692 Reactome: R-HSA-9029569 Reactome: R-HSA-9725371 Reactome: R-HSA-9759811 Reactome: R-HSA-9768778 Reactome: R-HSA-9824594 Reactome: R-HSA-9839394 |
| Cellular Localisation | Cytoplasm P-Body Cytoplasmic Ribonucleoprotein Granule Stress Granule Nucleus Co-Enriched In Cytoplasmic Foci With Tut4 In Developing Neurons Localizes Both In Nucleus And Cytoplasm But In The Adulthood It Is Only Cytoplasmic After Infection Relocalizes To The Denv Replication Complex In Perinuclear Regions |
| Alternative Antibody Names | Anti-Helicase Mov-10 antibody Anti-Armitage Homolog antibody Anti-Moloney Leukemia Virus 10 Protein antibody Anti-MOV10 antibody Anti-KIAA1631 antibody |
Information sourced from Uniprot.org