| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MORF4L1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MORF4L1 |
| Gene ID: |
10933 |
| Uniprot ID: |
MO4L1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MORF4L1 (NP_006782.1). |
| Immunogen Sequence: |
MAPKQDPKPKFQEGERVLCF HGPLLYEAKCVKVAIKDKQV KYFIHYSGWNKNWDEWVPES RVLKYVDTNLQKQRELQKAN QEQYAEGKMRGAAPGKKTSG |
| Function | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. |
| Protein Name | Mortality Factor 4-Like Protein 1Morf-Related Gene 15 ProteinProtein Msl3-1Transcription Factor-Like Protein Mrg15 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mortality Factor 4-Like Protein 1 antibodyAnti-Morf-Related Gene 15 Protein antibodyAnti-Protein Msl3-1 antibodyAnti-Transcription Factor-Like Protein Mrg15 antibodyAnti-MORF4L1 antibodyAnti-MRG15 antibodyAnti-FWP006 antibodyAnti-HSPC008 antibodyAnti-HSPC061 antibodyAnti-PP368 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
