| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MOB1A |
| Gene ID: |
55233 |
| Uniprot ID: |
MOB1A_HUMAN |
| Immunogen Region: |
150-250 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human MOB1A/MOB1B (NP_060691.2/NP_775739.1). |
| Immunogen Sequence: |
TILKRLFRVYAHIYHQHFDS VMQLQEEAHLNTSFKHFIFF VQEFNLIDRRELAPLQELIE KLGSKDR/MSFLFGSRSSKT FKPKKNIPEGSHQYELLKHA E |
| Tissue Specificity | Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. |
| Post Translational Modifications | Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. |
| Function | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. |
| Protein Name | Mob Kinase Activator 1aMob1 AlphaMob1aMob1 Homolog 1bMps One Binder Kinase Activator-Like 1b |
| Database Links | Reactome: R-HSA-2028269 |
| Alternative Antibody Names | Anti-Mob Kinase Activator 1a antibodyAnti-Mob1 Alpha antibodyAnti-Mob1a antibodyAnti-Mob1 Homolog 1b antibodyAnti-Mps One Binder Kinase Activator-Like 1b antibodyAnti-MOB1A antibodyAnti-C2orf6 antibodyAnti-MOB4B antibodyAnti-MOBK1B antibodyAnti-MOBKL1B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
