| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MOAP1 (1-351) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MOAP1 |
| Gene ID: |
64112 |
| Uniprot ID: |
MOAP1_HUMAN |
| Immunogen Region: |
1-351 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-351 of human MOAP1 (NP_071434.2). |
| Immunogen Sequence: |
MTLRLLEDWCRGMDMNPRKA LLIAGISQSCSVAEIEEALQ AGLAPLGEYRLLGRMFRRDE NRKVALVGLTAETSHALVPK EIPGKGGIWRVIFKPPDPDN TFLSRLNEFLAGEGMTVGEL SRALGHENGSLDPEQGMIPE MWAPMLAQALEALQPALQCL KYKKLRVFSGRESPEPGEEE FGRWMFHTTQMIKAWQVPDV EKRRRLLESLRGPALDVIRV LKINNPLITVDECLQALEE |
| Tissue Specificity | Widely expressed, with high levels in heart and brain. |
| Post Translational Modifications | Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1, this modification is inhibited by TRIM39. |
| Function | Retrotransposon-derived protein that forms virion-like capsids. Acts as an effector of BAX during apoptosis: enriched at outer mitochondria membrane and associates with BAX upon induction of apoptosis, facilitating BAX-dependent mitochondrial outer membrane permeabilization and apoptosis. Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Also promotes autophagy: promotes phagophore closure via association with ATG8 proteins. Acts as an inhibitor of the NFE2L2/NRF2 pathway via interaction with SQSTM1: interaction promotes dissociation of SQSTM1 inclusion bodies that sequester KEAP1, relieving inactivation of the BCR(KEAP1) complex. |
| Protein Name | Modulator Of Apoptosis 1Map-1Map1Paraneoplastic Antigen Ma4 |
| Cellular Localisation | CytoplasmCytosolMitochondrion Outer MembraneExtracellular Vesicle MembraneForms Virion-Like Extracellular Vesicles That Are Released From Cells |
| Alternative Antibody Names | Anti-Modulator Of Apoptosis 1 antibodyAnti-Map-1 antibodyAnti-Map1 antibodyAnti-Paraneoplastic Antigen Ma4 antibodyAnti-MOAP1 antibodyAnti-PNMA4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
