| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Matrix metalloproteinase-24 (520-600 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MMP24 |
| Gene ID: |
10893 |
| Uniprot ID: |
MMP24_HUMAN |
| Immunogen Region: |
520-600 aa |
| Specificity: |
MMP24 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 520-600 |
| Post Translational Modifications | Cleaved by a furin endopeptidase in the trans-Golgi network. |
| Function | Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. |
| Protein Name | Matrix Metalloproteinase-24Mmp-24Membrane-Type Matrix Metalloproteinase 5Mt-Mmp 5Mtmmp5Membrane-Type-5 Matrix MetalloproteinaseMt5-MmpMt5mmp Cleaved Into - Processed Matrix Metalloproteinase-24 |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | Matrix Metalloproteinase-24: Cell MembraneSingle-Pass Type I Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneRecycled Back To The Plasma Membrane Through The Trans-Golgi Network Via Interaction With Apba3Processed Matrix Metalloproteinase-24: SecretedExtracellular SpaceExtracellular MatrixAlso Shed From Cell Surface As Soluble ProteinaseBy A Proteolytic Cleavage |
| Alternative Antibody Names | Anti-Matrix Metalloproteinase-24 antibodyAnti-Mmp-24 antibodyAnti-Membrane-Type Matrix Metalloproteinase 5 antibodyAnti-Mt-Mmp 5 antibodyAnti-Mtmmp5 antibodyAnti-Membrane-Type-5 Matrix Metalloproteinase antibodyAnti-Mt5-Mmp antibodyAnti-Mt5mmp Cleaved Into - Processed Matrix Metalloproteinase-24 antibodyAnti-MMP24 antibodyAnti-MT5MMP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
