| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Malonyl-CoA decarboxylase, mitochondrial (243-293 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MLYCD |
| Gene ID: |
23417 |
| Uniprot ID: |
DCMC_HUMAN |
| Immunogen Region: |
243-293 aa |
| Specificity: |
This antibody detects endogenous levels of DCMC at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human DCMC at the amino acid range 243-293 |
| Post Translational Modifications | Acetylation at Lys-472 activates malonyl-CoA decarboxylase activity. Deacetylation at Lys-472 by SIRT4 represses activity, leading to promote lipogenesis. Interchain disulfide bonds may form in peroxisomes (Potential). Interchain disulfide bonds are not expected to form in the reducing environment of the cytoplasm and mitochondria. |
| Function | Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. May play a role in controlling the extent of ischemic injury by promoting glucose oxidation. |
| Protein Name | Malonyl-Coa Decarboxylase - MitochondrialMcd |
| Database Links | Reactome: R-HSA-390247 O95822-2Reactome: R-HSA-9033241 O95822-2 |
| Cellular Localisation | CytoplasmMitochondrion MatrixPeroxisomePeroxisome MatrixEnzymatically Active In All Three Subcellular Compartments |
| Alternative Antibody Names | Anti-Malonyl-Coa Decarboxylase - Mitochondrial antibodyAnti-Mcd antibodyAnti-MLYCD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
