| Post Translational Modifications | Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity. |
| Function | Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively. |
| Protein Name | Carbohydrate-Responsive Element-Binding ProteinChrebpClass D Basic Helix-Loop-Helix Protein 14Bhlhd14Mlx InteractorMlx-Interacting Protein-LikeWs Basic-Helix-Loop-Helix Leucine Zipper ProteinWs-BhlhWilliams-Beuren Syndrome Chromosomal Region 14 Protein |
| Database Links | Reactome: R-HSA-163358Reactome: R-HSA-163680Reactome: R-HSA-163765Reactome: R-HSA-163767 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Carbohydrate-Responsive Element-Binding Protein antibodyAnti-Chrebp antibodyAnti-Class D Basic Helix-Loop-Helix Protein 14 antibodyAnti-Bhlhd14 antibodyAnti-Mlx Interactor antibodyAnti-Mlx-Interacting Protein-Like antibodyAnti-Ws Basic-Helix-Loop-Helix Leucine Zipper Protein antibodyAnti-Ws-Bhlh antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 14 Protein antibodyAnti-MLXIPL antibodyAnti-BHLHD14 antibodyAnti-MIO antibodyAnti-WBSCR14 antibody |
Information sourced from Uniprot.org
