| Short Description : | Goat polyclonal antibody anti-MLLT10/AF10 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications: | Pep-ELISA/WB |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Experiments gave bands at approx 140kDa and 60kDa in Rat Testis lysates. These bands correspond to earlier findings with different antibodies from other sources.. This protein has a ca |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | MLLT10 |
| Gene ID: | 8028 |
| Uniprot ID: | AF10_HUMAN |
| Accession Number: | NP_004632.1; NP_001009569.1 |
| Immunogen Region: | Internal |
| Immunogen Sequence: | RLEDTTARFTNAN |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_004632.1; NP_001009569.1). |
| Function | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation. |
| Protein Name | Protein Af-10All1-Fused Gene From Chromosome 10 Protein |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Protein Af-10 antibodyAnti-All1-Fused Gene From Chromosome 10 Protein antibodyAnti-MLLT10 antibodyAnti-AF10 antibody |
Information sourced from Uniprot.org
