Anti-MKNK2 antibody (C-Term) (STJA0003692)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide from the C-terminal region, specific to the human Mnk2b isoform.
General Information
| Short Description | Rabbit polyclonal anti-Mnk2b (C-Term) for use in WB in Human and Non-Human Primates samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Non-Human Primates |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MKNK2 |
| Gene ID | 2872 |
| Uniprot ID | MKNK2_HUMAN |
| Immunogen | Synthetic peptide from the C-terminal region, specific to the human Mnk2b isoform. |
| Immunogen Region | C-Term |
Additional Info
| Tissue Specificity | Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. |
| Post Translational Modifications | Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A. |
| Function | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. |
| Protein Name | Map Kinase-Interacting Serine/Threonine-Protein Kinase 2Map Kinase Signal-Integrating Kinase 2Mapk Signal-Integrating Kinase 2Mnk2 |
| Database Links | |
| Cellular Localisation | Isoform 2: NucleusPml BodyIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Map Kinase-Interacting Serine/Threonine-Protein Kinase 2 antibodyAnti-Map Kinase Signal-Integrating Kinase 2 antibodyAnti-Mapk Signal-Integrating Kinase 2 antibodyAnti-Mnk2 antibodyAnti-MKNK2 antibodyAnti-GPRK7 antibodyAnti-MNK2 antibody |
Information sourced from Uniprot.org