Anti-Mitochondrial Import Receptor Subunit TOM20 Homolog antibody (Cyt Dom) (STJA0040640)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenRecombinant protein encompassing the full cytoplasmic domain of human TOMM20
General Information
| Short Description | Chicken polyclonal anti-Mitochondrial Import Receptor Subunit TOM20 Homolog (Cyt Dom) for use in ICC, IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC/WB |
| Host | Chicken |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Concentration | 200 µg/mL |
| Purification | Affinity-Purified IgY |
| Dilution Range | WB Brain 1:500-1:1000ICC 1:50-1:200 |
| Formulation | Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS, pH 7.2) with sodium azide (0.02%, w/v) added as a preservative." |
| Storage Instruction | Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody. |
Target Information
| Gene Symbol | TOMM20 |
| Gene ID | 9804 |
| Uniprot ID | TOM20_HUMAN |
| Immunogen | Recombinant protein encompassing the full cytoplasmic domain of human TOMM20 |
| Immunogen Region | Cyt Dom |
| Immunogen Sequence | Human |
| Specificity | No cross-reactivity reported |
Additional Info
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. |
| Protein Name | Mitochondrial Import Receptor Subunit Tom20 HomologMitochondrial 20 Kda Outer Membrane ProteinOuter Mitochondrial Membrane Receptor Tom20 |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-5205685Reactome: R-HSA-5689880 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Import Receptor Subunit Tom20 Homolog antibodyAnti-Mitochondrial 20 Kda Outer Membrane Protein antibodyAnti-Outer Mitochondrial Membrane Receptor Tom20 antibodyAnti-TOMM20 antibodyAnti-KIAA0016 antibody |
Information sourced from Uniprot.org