Anti-MIF antibody (1-115 aa) [4E4] (STJA0041518)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human MIF (1-115 aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-MIF (1-115 aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4E4 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MIF |
| Gene ID | 4282 |
| Uniprot ID | MIF_HUMAN |
| Accession Number | NP_002406 |
| Immunogen | Recombinant human MIF (1-115 aa) purified from E. coli |
| Immunogen Region | 1-115 aa |
Additional Info
| Function | Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. |
| Protein Name | Macrophage Migration Inhibitory FactorMifGlycosylation-Inhibiting FactorGifL-Dopachrome IsomeraseL-Dopachrome TautomerasePhenylpyruvate Tautomerase |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-6798695Reactome: R-HSA-8950505 |
| Cellular Localisation | SecretedCytoplasmDoes Not Have A Cleavable Signal Sequence And Is Secreted Via A SpecializedNon-Classical PathwaySecreted By Macrophages Upon Stimulation By Bacterial Lipopolysaccharide (Lps)Or By MTuberculosis Antigens |
| Alternative Antibody Names | Anti-Macrophage Migration Inhibitory Factor antibodyAnti-Mif antibodyAnti-Glycosylation-Inhibiting Factor antibodyAnti-Gif antibodyAnti-L-Dopachrome Isomerase antibodyAnti-L-Dopachrome Tautomerase antibodyAnti-Phenylpyruvate Tautomerase antibodyAnti-MIF antibodyAnti-GLIF antibodyAnti-MMIF antibody |
Information sourced from Uniprot.org