| Short Description : | Rabbit polyclonal MIER1 (110-160) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MIER1 |
| Gene ID: | 57708 |
| Uniprot ID: | MIER1_HUMAN |
| Immunogen Region: | 110-160 |
| Immunogen Sequence: | SGENKEENIKDSSGQEDETQ SSNDDPSQSVASQDAQEIIR PRRCKYFDTNS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-160 of human MIER1 (Q8N108). |
| Tissue Specificity | Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor. |
| Function | Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing. |
| Protein Name | Mesoderm Induction Early Response Protein 1Early Response 1Er1Mi-Er1Hmi-Er1 |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: NucleusIsoform 3: NucleusIsoform 4: CytoplasmIsoform 5: CytoplasmIsoform 6: Cytoplasm |
| Alternative Antibody Names | Anti-Mesoderm Induction Early Response Protein 1 antibodyAnti-Early Response 1 antibodyAnti-Er1 antibodyAnti-Mi-Er1 antibodyAnti-Hmi-Er1 antibodyAnti-MIER1 antibodyAnti-KIAA1610 antibody |
Information sourced from Uniprot.org
