| Function | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Functions also as an electroneutral mitochondrial proton/potassium exchanger. Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria. However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome. |
| Protein Name | Growth Hormone-Inducible Transmembrane ProteinDermal Papilla-Derived Protein 2Mitochondrial Morphology And Cristae Structure 1Mics1Transmembrane Bax Inhibitor Motif-Containing Protein 5 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Growth Hormone-Inducible Transmembrane Protein antibodyAnti-Dermal Papilla-Derived Protein 2 antibodyAnti-Mitochondrial Morphology And Cristae Structure 1 antibodyAnti-Mics1 antibodyAnti-Transmembrane Bax Inhibitor Motif-Containing Protein 5 antibodyAnti-GHITM antibodyAnti-DERP2 antibodyAnti-MICS1 antibodyAnti-TMBIM5 antibodyAnti-My021 antibodyAnti-UNQ244 antibodyAnti-PRO281 antibody |
Information sourced from Uniprot.org
