Anti-MICS1/GHITM antibody (117-127) (STJ72129)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-MICS1/GHITM (117-127) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 38kDa band observed in Human Brain (Cerebral Cortex and Cerebellum) lysates (calculated MW of 37.2kDa according to NP_055209.2). Recommended concentration: 1-3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | GHITM |
| Gene ID | 27069 |
| Uniprot ID | GHITM_HUMAN |
| Accession Number | NP_055209.2 |
| Immunogen Region | 117-127 |
| Immunogen Sequence | PQYVKDRIHST |
Additional Info
| Function | Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport. Mediates proton-dependent calcium efflux from mitochondrion. Functions also as an electroneutral mitochondrial proton/potassium exchanger. Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c. Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria. However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome. |
| Protein Name | Growth Hormone-Inducible Transmembrane ProteinDermal Papilla-Derived Protein 2Mitochondrial Morphology And Cristae Structure 1Mics1Transmembrane Bax Inhibitor Motif-Containing Protein 5 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Growth Hormone-Inducible Transmembrane Protein antibodyAnti-Dermal Papilla-Derived Protein 2 antibodyAnti-Mitochondrial Morphology And Cristae Structure 1 antibodyAnti-Mics1 antibodyAnti-Transmembrane Bax Inhibitor Motif-Containing Protein 5 antibodyAnti-GHITM antibodyAnti-DERP2 antibodyAnti-MICS1 antibodyAnti-TMBIM5 antibodyAnti-My021 antibodyAnti-UNQ244 antibodyAnti-PRO281 antibody |
Information sourced from Uniprot.org