| Host: | Rabbit |
| Applications: | FC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-MICB for use in FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | DM168 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Purification: | Affinity Chromatography |
| Dilution Range: | FC 1:50-1:100ELISA 1:10000 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | MICB |
| Gene ID: | 4277 |
| Uniprot ID: | MICB_HUMAN |
| Immunogen: | Recombinant human MICB protein |
| Tissue Specificity | Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue. |
| Post Translational Modifications | Proteolytically cleaved and released from the cell surface of tumor cells. |
| Function | Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8+ alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production. |
| Protein Name | Mhc Class I Polypeptide-Related Sequence BMic-B |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinBinding To Human Cytomegalovirus Glycoprotein Ul16 Causes Sequestration In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Mhc Class I Polypeptide-Related Sequence B antibodyAnti-Mic-B antibodyAnti-MICB antibodyAnti-PERB11.2 antibody |
Information sourced from Uniprot.org
