| Tissue Specificity | Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. |
| Function | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L.acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export. |
| Protein Name | F-Actin-Monooxygenase Mical1Molecule Interacting With Casl Protein 1Mical-1Nedd9-Interacting Protein With Calponin Homology And Lim Domains |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCytoskeletonEndosome MembraneMidbodyAccumulates Transiently At The Abscission Site Before Abscission OccursColocalized With Graf1/Arhgap26 And Graf2/Arhgap10Rab8aRab8b And Rab10 On Endosomal Tubules |
| Alternative Antibody Names | Anti-F-Actin-Monooxygenase Mical1 antibodyAnti-Molecule Interacting With Casl Protein 1 antibodyAnti-Mical-1 antibodyAnti-Nedd9-Interacting Protein With Calponin Homology And Lim Domains antibodyAnti-MICAL1 antibodyAnti-MICAL antibodyAnti-NICAL antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and MAD1/MAD1L1 Rabbit polyclonal antibody knockdown (KD) 293T cells, using [KD Validated] MAD1/MAD1L1 Rabbit polyclonal antibody (STJ11104645) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/177289/368928/STJ11104645_1__26785.1713134409.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and MAD1/MAD1L1 Rabbit polyclonal antibody knockdown (KD) 293T cells, using [KD Validated] MAD1/MAD1L1 Rabbit polyclonal antibody (STJ11104645) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.")
