| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MICAL1 (718-1067) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MICAL1 |
| Gene ID: |
64780 |
| Uniprot ID: |
MICA1_HUMAN |
| Immunogen Region: |
718-1067 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 718-1067 of human MICAL1 (NP_073602.3). |
| Immunogen Sequence: |
HRSCFRCHTCEATLWPGGYE QHPGDGHFYCLQHLPQTDHK AEGSDRGPESPELPTPSENS MPPGLSTPTASQEGAGPVPD PSQPTRRQIRLSSPERQRLS SLNLTPDPEMEPPPKPPRSC SALARHALESSFVGWGLPVQ SPQALVAMEKEEKESPFSSE EEEEDVPLDSDVEQALQTFA KTSGTMNNYPTWRRTLLRRA KEEEMKRFCKAQTIQRRLNE IEAALRELEAEGVKLELAL |
| Tissue Specificity | Expressed in the thymus, lung, spleen, kidney, testis and hematopoietic cells. |
| Function | Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L.acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export. |
| Protein Name | F-Actin-Monooxygenase Mical1Molecule Interacting With Casl Protein 1Mical-1Nedd9-Interacting Protein With Calponin Homology And Lim Domains |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCytoskeletonEndosome MembraneMidbodyAccumulates Transiently At The Abscission Site Before Abscission OccursColocalized With Graf1/Arhgap26 And Graf2/Arhgap10Rab8aRab8b And Rab10 On Endosomal Tubules |
| Alternative Antibody Names | Anti-F-Actin-Monooxygenase Mical1 antibodyAnti-Molecule Interacting With Casl Protein 1 antibodyAnti-Mical-1 antibodyAnti-Nedd9-Interacting Protein With Calponin Homology And Lim Domains antibodyAnti-MICAL1 antibodyAnti-MICAL antibodyAnti-NICAL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
