Anti-MIB2 antibody (300-580) (STJ119853)

Name: Anti-MIB2 antibody (300-580) (STJ119853)
SKU: STJ119853
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ119853

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Short Description	Rabbit polyclonal MIB2 (300-580) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	MIB2
Gene ID	142678
Uniprot ID	MIB2_HUMAN
Immunogen Region	300-580
Immunogen Sequence	ASVTWADGTTNVYRVGHKGK VDLKCVGEAAGGFYYKDHLP RLGKPAELQRRVSADSQPFQ HGDKVKCLLDTDVLREMQEG HGGWNPRMAEFIGQTGTVHR ITDRGDVRVQFNHETRWTFH PGALTKHHSFWVGDVVRVIG DLDTVKRLQAGHGEWTDDMA PALGRVGKVVKVFGDGNLRV AVAGQRWTFSPSCLVAYRPE EDANLDVAERARENKSSLSV ALDKLRAQKSDPEHPGRLV
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1).

Tissue Specificity	Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.
Post Translational Modifications	Ubiquitinated. Possibly via autoubiquitination.
Function	E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
Protein Name	E3 Ubiquitin-Protein Ligase Mib2 Mind Bomb Homolog 2 Novel Zinc Finger Protein Novelzin Putative Nf-Kappa-B-Activating Protein 002n Ring-Type E3 Ubiquitin Transferase Mib2 Skeletrophin Zinc Finger Zz Type With Ankyrin Repeat Domain Protein 1
Database Links	Reactome: R-HSA-2122948 Reactome: R-HSA-2644606 Reactome: R-HSA-2691232 Reactome: R-HSA-2894862 Reactome: R-HSA-2979096 Reactome: R-HSA-5357786 Reactome: R-HSA-5357905 Reactome: R-HSA-9013507 Reactome: R-HSA-983168
Cellular Localisation	Cytoplasm Endosome Colocalizes With Endosomal Compartments
Alternative Antibody Names	Anti-E3 Ubiquitin-Protein Ligase Mib2 antibody Anti-Mind Bomb Homolog 2 antibody Anti-Novel Zinc Finger Protein antibody Anti-Novelzin antibody Anti-Putative Nf-Kappa-B-Activating Protein 002n antibody Anti-Ring-Type E3 Ubiquitin Transferase Mib2 antibody Anti-Skeletrophin antibody Anti-Zinc Finger Zz Type With Ankyrin Repeat Domain Protein 1 antibody Anti-MIB2 antibody Anti-SKD antibody Anti-ZZANK1 antibody

Information sourced from Uniprot.org