| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MIB2 (300-580) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MIB2 |
| Gene ID: |
142678 |
| Uniprot ID: |
MIB2_HUMAN |
| Immunogen Region: |
300-580 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1). |
| Immunogen Sequence: |
ASVTWADGTTNVYRVGHKGK VDLKCVGEAAGGFYYKDHLP RLGKPAELQRRVSADSQPFQ HGDKVKCLLDTDVLREMQEG HGGWNPRMAEFIGQTGTVHR ITDRGDVRVQFNHETRWTFH PGALTKHHSFWVGDVVRVIG DLDTVKRLQAGHGEWTDDMA PALGRVGKVVKVFGDGNLRV AVAGQRWTFSPSCLVAYRPE EDANLDVAERARENKSSLSV ALDKLRAQKSDPEHPGRLV |
| Tissue Specificity | Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney. |
| Post Translational Modifications | Ubiquitinated. Possibly via autoubiquitination. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. |
| Protein Name | E3 Ubiquitin-Protein Ligase Mib2Mind Bomb Homolog 2Novel Zinc Finger ProteinNovelzinPutative Nf-Kappa-B-Activating Protein 002nRing-Type E3 Ubiquitin Transferase Mib2SkeletrophinZinc Finger Zz Type With Ankyrin Repeat Domain Protein 1 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-9013507Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmEndosomeColocalizes With Endosomal Compartments |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Mib2 antibodyAnti-Mind Bomb Homolog 2 antibodyAnti-Novel Zinc Finger Protein antibodyAnti-Novelzin antibodyAnti-Putative Nf-Kappa-B-Activating Protein 002n antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mib2 antibodyAnti-Skeletrophin antibodyAnti-Zinc Finger Zz Type With Ankyrin Repeat Domain Protein 1 antibodyAnti-MIB2 antibodyAnti-SKD antibodyAnti-ZZANK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
