| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MIB2 |
| Gene ID: | 142678 |
| Uniprot ID: | MIB2_HUMAN |
| Immunogen Region: | 300-580 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-580 of human MIB2 (NP_001164158.1). |
| Immunogen Sequence: | ASVTWADGTTNVYRVGHKGK VDLKCVGEAAGGFYYKDHLP RLGKPAELQRRVSADSQPFQ HGDKVKCLLDTDVLREMQEG HGGWNPRMAEFIGQTGTVHR ITDRGDVRVQFNHETRWTFH PGALTKHHSFWVGDVVRVIG DLDTVKRLQAGHGEWTDDMA PALGRVGKVVKVFGDGNLRV AVAGQRWTFSPSCLVAYRPE EDANLDVAERARENKSSLSV ALDKLRAQKSDPEHPGRLV |
| Tissue Specificity | Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney. |
| Post Translational Modifications | Ubiquitinated. Possibly via autoubiquitination. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. |
| Protein Name | E3 Ubiquitin-Protein Ligase Mib2Mind Bomb Homolog 2Novel Zinc Finger ProteinNovelzinPutative Nf-Kappa-B-Activating Protein 002nRing-Type E3 Ubiquitin Transferase Mib2SkeletrophinZinc Finger Zz Type With Ankyrin Repeat Domain Protein 1 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-9013507Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmEndosomeColocalizes With Endosomal Compartments |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Mib2 antibodyAnti-Mind Bomb Homolog 2 antibodyAnti-Novel Zinc Finger Protein antibodyAnti-Novelzin antibodyAnti-Putative Nf-Kappa-B-Activating Protein 002n antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mib2 antibodyAnti-Skeletrophin antibodyAnti-Zinc Finger Zz Type With Ankyrin Repeat Domain Protein 1 antibodyAnti-MIB2 antibodyAnti-SKD antibodyAnti-ZZANK1 antibody |
Information sourced from Uniprot.org
