| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase MGRN1 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MGRN1 |
| Gene ID: |
23295 |
| Uniprot ID: |
MGRN1_HUMAN |
| Specificity: |
MGRN1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling. |
| Protein Name | E3 Ubiquitin-Protein Ligase Mgrn1Mahogunin Ring Finger Protein 1Ring Finger Protein 156Ring-Type E3 Ubiquitin Transferase Mgrn1 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Early EndosomeThe Endosomal Localization Is Dependent On The Interaction With Tsg101Isoform 1: CytoplasmCytosolNucleusTranslocation From The Cytosol To The Nucleus Is Seen Only In The Presence Of Mc1r And Mc4rBut Not Tbxa2rExcluded From NucleoliIsoform 2: CytoplasmIsoform 3: CytoplasmCell MembraneIsoform 4: Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Mgrn1 antibodyAnti-Mahogunin Ring Finger Protein 1 antibodyAnti-Ring Finger Protein 156 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mgrn1 antibodyAnti-MGRN1 antibodyAnti-KIAA0544 antibodyAnti-RNF156 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
