Host: | Mouse |
Applications: | WB/ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Mouse monoclonal antibody anti-Methylated-DNA--protein-cysteine methyltransferase (1-100) is suitable for use in Western Blot and ELISA research applications. |
Clonality : | Monoclonal |
Clone ID : | PTR2300 |
Conjugation: | Unconjugated |
Isotype: | IgG2bk |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | MGMT |
Gene ID: | 4255 |
Uniprot ID: | MGMT_HUMAN |
Immunogen Region: | 1-100 |
Specificity: | This antibody detects endogenous levels of MGMT at Human, Predict react with Mouse;Rat |
Immunogen: | Synthesized peptide derived from human MGMT AA range: 1-100 |
Function | Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. |
Protein Name | Methylated-Dna--Protein-Cysteine Methyltransferase6-O-Methylguanine-Dna MethyltransferaseMgmtO-6-Methylguanine-Dna-Alkyltransferase |
Database Links | Reactome: R-HSA-5657655 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Methylated-Dna--Protein-Cysteine Methyltransferase antibodyAnti-6-O-Methylguanine-Dna Methyltransferase antibodyAnti-Mgmt antibodyAnti-O-6-Methylguanine-Dna-Alkyltransferase antibodyAnti-MGMT antibody |
Information sourced from Uniprot.org