Anti-MGME1 antibody (STJA0004714)

SKU:
STJA0004714
£139.50 - £403.50
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Short Description :Rabbit polyclonal anti-Mitochondrial Genome Maintenance Exonuclease 1 for use in IHC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC/ELISA
Host:Rabbit
Reactivity:Human
Note:FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:1.26 mg/mL
Purification:Antigen affinity purification
Dilution Range:IHC 1:50-1:200
Formulation:PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Instruction:Store at-20°C for the long term, and avoid freeze-thaw cycles.
Gene Symbol:MGME1
Gene ID:92667
Uniprot ID:MGME1_HUMAN
Immunogen:Fusion protein of human MGME1
Function Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endonuclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.
Protein Name Mitochondrial Genome Maintenance Exonuclease 1
Database Links Reactome: R-HSA-9913635
Cellular Localisation Mitochondrion
Alternative Antibody Names Anti-Mitochondrial Genome Maintenance Exonuclease 1 antibody
Anti-MGME1 antibody
Anti-C20orf72 antibody
Anti-DDK1 antibody

Information sourced from Uniprot.org

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